Nebraska Sen. Ben Sasse is expected to resign in the near future, likely to become the new president at the University of Florida. He is the only finalist in that search. Per Politico, Sasse, in his second term, has "made a name for himself as a consistent Trump critic in Congress as well as a reliable conservative vote."
With the planned departure coming so close to the 2022 election, Gov. Pete Ricketts (R) will be able to appoint an interim replacement, who will serve until a special election is held in November, 2024. The winner of that election will complete the final two years of the term. Nebraska's other Senate seat, held by Republican Deb Fischer will also be on the 2024 ballot for a regular six-year term.